The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling

In plants, perception of invading pathogens involves cell-surface immune receptor kinases. Here, we report that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RALF) propeptides to inhibit plant immunity. This inhibition is mediated by the malectin-like receptor...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 2017-01, Vol.355 (6322), p.287-289
Hauptverfasser: Stegmann, Martin, Monaghan, Jacqueline, Smakowska-Luzan, Elwira, Rovenich, Hanna, Lehner, Anita, Holton, Nicholas, Belkhadir, Youssef, Zipfel, Cyril
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Sprache:eng
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Zusammenfassung:In plants, perception of invading pathogens involves cell-surface immune receptor kinases. Here, we report that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RALF) propeptides to inhibit plant immunity. This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced complex formation of the immune receptor kinases EF-TU RECEPTOR (EFR) and FLAGELLIN-SENSING 2 (FLS2) with their co-receptor BRASSINOSTEROID INSENSITIVE 1–ASSOCIATED KINASE 1 (BAK1) to initiate immune signaling. We show that FER acts as a RALF-regulated scaffold that modulates receptor kinase complex assembly. A similar scaffolding mechanism may underlie FER function in other signaling pathways.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.aal2541