Altered gut microbiota and activity in a murine model of autism spectrum disorders

Highlight • In utero exposure to valproic acid leads to altered postnatal microbial colonization and activity in mice, with preponderance in male offspring.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2014-03, Vol.37, p.197-206
Hauptverfasser:	de Theije, Caroline G.M, Wopereis, Harm, Ramadan, Mohamed, van Eijndthoven, Tiemen, Lambert, Jolanda, Knol, Jan, Garssen, Johan, Kraneveld, Aletta D, Oozeer, Raish
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic Acid - analysis Allergy and Immunology Animals Autism spectrum disorders brain Butyrate Butyric Acid - analysis Child Development Disorders, Pervasive - metabolism Child Development Disorders, Pervasive - microbiology children Disease Models, Animal exposure Female Gut microbiota host interactions intestinal microbiota Intestine, Large - metabolism Intestine, Large - microbiology Lactic Acid - analysis Male maternal separation Mice Mice, Inbred BALB C Microbiota - drug effects Microbiota - physiology microflora Neurodevelopment onset autism Prenatal propionic-acid Psychiatry Sex Factors Short chain fatty acids Valproate valproic acid Valproic Acid - toxicity
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Beschreibung
Zusammenfassung:	Highlight • In utero exposure to valproic acid leads to altered postnatal microbial colonization and activity in mice, with preponderance in male offspring.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2013.12.005