Modulatory effects of quercetin on proliferation and differentiation of the human colorectal cell line Caco-2

The effect of the dietary flavonoid quercetin was investigated on proliferation and differentiation of the human colon cancer cell line Caco-2. Confluent Caco-2 monolayers exposed to quercetin showed a biphasic effect on cell proliferation and a decrease in cell differentiation (0.001< P

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2006-07, Vol.238 (2), p.248-259
Hauptverfasser:	Dihal, Ashwin A., Woutersen, Ruud A., Ommen, Ben van, Rietjens, Ivonne M.C.M., Stierum, Rob H.
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption Anticarcinogenic Agents - pharmacology apoptosis Caco-2 Caco-2 Cells Cell Differentiation - drug effects Cell Proliferation - drug effects colon-cancer cells Colorectal cancer Colorectal Neoplasms - pathology Colorectal Neoplasms - prevention & control dietary flavonoids Differentiation Drug Stability estrogen-receptor expression genistein glycosides Humans in-vitro Kinases Medical research Metabolism Metabolites Proliferation Quercetin Quercetin - chemistry Quercetin - metabolism Quercetin - pharmacology Small intestine
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Beschreibung
Zusammenfassung:	The effect of the dietary flavonoid quercetin was investigated on proliferation and differentiation of the human colon cancer cell line Caco-2. Confluent Caco-2 monolayers exposed to quercetin showed a biphasic effect on cell proliferation and a decrease in cell differentiation (0.001< P
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2005.07.007