The application of DNA microarrays in gene expression analysis

DNA microarray technology is a new and powerful technology that will substantially increase the speed of molecular biological research. This paper gives a survey of DNA microarray technology and its use in gene expression studies. The technical aspects and their potential improvements are discussed....

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Veröffentlicht in:Journal of biotechnology 2000-03, Vol.78 (3), p.271-280
Hauptverfasser: van Hal, Nicole L.W, Vorst, Oscar, van Houwelingen, Adèle M.M.L, Kok, Esther J, Peijnenburg, Ad, Aharoni, Asaph, van Tunen, Arjen J, Keijer, Jaap
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Sprache:eng
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Zusammenfassung:DNA microarray technology is a new and powerful technology that will substantially increase the speed of molecular biological research. This paper gives a survey of DNA microarray technology and its use in gene expression studies. The technical aspects and their potential improvements are discussed. These comprise array manufacturing and design, array hybridisation, scanning, and data handling. Furthermore, it is discussed how DNA microarrays can be applied in the working fields of: safety, functionality and health of food and gene discovery and pathway engineering in plants.
ISSN:0168-1656
1873-4863
DOI:10.1016/S0168-1656(00)00204-2