Total Synthesis and Bioactivity of Some Naturally Occurring Pterulones

The naturally occurring pterulones 1, 3, and 13 were synthesized in high overall yield from readily available methyl 3-(2-propenyl)-4-(2-propenyloxy)benzoate (6) by employing ring-closing metathesis (RCM) as a key step. The biological activities of the synthesized pterulones were tested using cells...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2002-04, Vol.65 (4), p.558-561
Hauptverfasser:	Gruijters, Bas W. T, van Veldhuizen, Albertus, Weijers, Carel A. G. M, Wijnberg, Joannes B. P. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Agaricales - chemistry Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Benzoates - chemistry Benzoxepins - chemistry Benzoxepins - isolation & purification Benzoxepins - pharmacology Biological and medical sciences Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Laboratorium voor Organische chemie Laboratory for Organic Chemistry Latex - chemistry Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Organic Chemistry Organische Chemie Pharmacology. Drug treatments Preparations and properties Rhodotorula - drug effects Saccharomyces cerevisiae - drug effects Stereoisomerism VLAG
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Zusammenfassung:	The naturally occurring pterulones 1, 3, and 13 were synthesized in high overall yield from readily available methyl 3-(2-propenyl)-4-(2-propenyloxy)benzoate (6) by employing ring-closing metathesis (RCM) as a key step. The biological activities of the synthesized pterulones were tested using cells of Rhodotorula glutinis and Saccharomyces cerevisiae.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np010510m