Interaction between the STAT4rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus

Interaction between the STAT4rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus

Objective To investigate how genetics influence the risk of smoking-related systemic lupus erythematosus (SLE) manifestations. Methods Patients with SLE (n(discovery cohort)=776, n(replication cohort)=836) were genotyped using the 200K Immunochip single nucleotide polymorphisms (SNP) Array (Illumina...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Reid, Sarah, Hagberg, Niklas, Sandling, Johanna K, Alexsson, Andrei, Pucholt, Pascal, Sjowall, Christopher, Lerang, Karoline, Jonsen, Andreas, Gunnarsson, Iva, Syvänen, Ann-Christine, Troldborg, Anne Margrethe, Voss, Anne, Bengtsson, Anders A, Molberg, Oyvind, Jacobsen, Soren, Svenungsson, Elisabet, Rönnblom, Lars, Leonard, Dag
Format: Artikel
Sprache:eng
Schlagworte:
Reumatologi och inflammation
Rheumatology and Autoimmunity
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Objective To investigate how genetics influence the risk of smoking-related systemic lupus erythematosus (SLE) manifestations. Methods Patients with SLE (n(discovery cohort)=776, n(replication cohort)=836) were genotyped using the 200K Immunochip single nucleotide polymorphisms (SNP) Array (Illumina) and a custom array. Sixty SNPs with SLE association (p
DOI:10.1136/annrheumdis-2020-219727