The Wittig Bioconjugation of Maleimide Derived, Water Soluble Phosphonium Ylides to Aldehyde-Tagged Proteins

The Wittig Bioconjugation of Maleimide Derived, Water Soluble Phosphonium Ylides to Aldehyde-Tagged Proteins

Herein we disclose the transformation of maleimides into water-soluble tris(2-carboxyethyl)phosphonium ylides and their subsequent application in the bioconjugation of protein- and peptide-linked aldehydes. The new entry into Wittig bioconjugate chemistry proceeds under mild conditions and relies on...

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Hauptverfasser: Hartmann, Rafael W, Pijnappel, Matthijs, Nilvebrant, Johan, Helgudottir, Hildur Run, Asbjarnarson, Arni, Traustadottir, Gunnhildur Asta, Gudjonsson, Thorarinn, Nygren, Per-Åke, Lehmann, Fredrik, Odell, Luke R
Format: Artikel
Sprache:eng
Schlagworte:
Bioconjugation
Biomolecular Chemistry
Cytotoxicity
Läkemedelskemi
Medicinal Chemistry
Organic Chemistry
Organic Synthesis
Organisk kemi
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Beschreibung
Zusammenfassung:Herein we disclose the transformation of maleimides into water-soluble tris(2-carboxyethyl)phosphonium ylides and their subsequent application in the bioconjugation of protein- and peptide-linked aldehydes. The new entry into Wittig bioconjugate chemistry proceeds under mild conditions and relies on highly water soluble reagents, which are likely already part of most biochemists’ inventory. Authors in thesis list of papers: Hartmann, R. W., Pijnappel, M., Nilvebrant, J., Nygren, P.-Å., Lehmann, F., Odell, L. R.
DOI:10.1039/D1OB01155C