System and method for active cyberattack defense

Computing systems with dynamic architectures may be used to secure against code-injection attacks and other exploits. A system may generate multiple representations of instructions or other data associated with each of a set of configurations of the system. The system may periodically or randomly change configurations such that malicious code that is executable in one configuration cannot be executed in another configuration. A system may also detect malicious code by comparing code previously generated in one representation with different representations of the same code. If, during execution of a representation of a program code, the system determines that the representation specifies instructions that differ from other representations of the same program code, they system may stop executing the compromised program code, change its configuration, and continue to execute another representation of the program code that has not been compromised.