Antisense oligonucleotide controlling expression amount of TDP-43 and use thereof

Antisense oligonucleotide controlling expression amount of TDP-43 and use thereof

The present invention provides a suppression type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in any of SEQ ID NOs: 2-4, and a promotion type antisense ol...

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Bibliographische Detailangaben
Hauptverfasser: Osaka University, Aichi Medical University, KNC Laboratories Co., Ltd
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention provides a suppression type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in any of SEQ ID NOs: 2-4, and a promotion type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in SEQ ID NO: 5.