Synthetic gene for expressing Sm-14 in

Pichia pastoris Schistosoma mansoniPichia pastoris P. pastoris The production of recombinant proteins using a synthetic gene for increased expression of the protein in is disclosed. More specifically, disclosed is a process for producing a recombinant Sm14 protein of , by providing a synthetic gene for increased production of Sm14 protein, producing the gene and genetically manipulating the strain with the gene in order to produce a vaccine effectively. Improved methods are also provided for producing and purifying this protein from cells, which can be scaled for industrial production.