Aryl-substituted bridged or fused diamines as modulators of leukotriene A ydrolase

Aryl-substituted bridged or fused diamines as modulators of leukotriene A ydrolase

4 44Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene Ahydrolase (LTAH or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediat...

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Hauptverfasser: Bacani, Genesis M, Bembenek, Scott D, Eccles, Wendy, Edwards, James P, Epperson, Matthew T, Gomez, Laurent, Grice, Cheryl A, Kearney, Aaron M, Landry-Bayle, Adrienne M, Lee-Dutra, Alice, McClure, Kelly J, Mirzadegan, Taraneh, Santillán, Jr, Alexandro
Format: Patent
Sprache:eng
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Zusammenfassung:4 44Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene Ahydrolase (LTAH or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTAH activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.