Compositions and methods for suppression of amyloid plaque formation associated with neurodegenerative disorders

The invention provides methods and compositions for reducing or inhibiting net beta-amyloid peptide production and/or amyloid plaque formation. The methods and compositions involve administering a netrin-1 polypeptide or netrin-1 therapeutic to a subject in need thereof.

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Bibliographische Detailangaben
Hauptverfasser: Mehlen, Patrick, Bredesen, Dale E, Calheiros-Lourenco, Filipe, Galvan, Veronica
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention provides methods and compositions for reducing or inhibiting net beta-amyloid peptide production and/or amyloid plaque formation. The methods and compositions involve administering a netrin-1 polypeptide or netrin-1 therapeutic to a subject in need thereof.