Pyrimidyl cyclopentanes as Akt protein kinase inhibitors

The present invention provides compounds of Formula (I) including tautomers, resolved enantiomers, resolved diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as Akt protein kinase inhibitor...

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Bibliographische Detailangaben
Hauptverfasser: Banka, Anna L, Blake, James F, Bencsik, Josef R, Fong, Kin Chiu, Hentemann, Martin F, Sammond, Douglas M, Mitchell, Ian S, Xu, Rui, Wallace, Eli M, Tang, Tony
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention provides compounds of Formula (I) including tautomers, resolved enantiomers, resolved diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as Akt protein kinase inhibitors and for the treatment of Akt-mediated diseases, for example, hyperproliferative diseases such as cancer.