Substituted benzazoles and methods of their use as inhibitors of raf kinase

Substituted benzazoles and methods of their use as inhibitors of raf kinase

New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disor...

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Bibliographische Detailangaben
Hauptverfasser: Amiri, Payman, Fantl, Wendy, Levine, Barry Haskell, Poon, Daniel J, Ramurthy, Savithri, Renhowe, Paul A, Subramanian, Sharadha, Sung, Leonard
Format: Patent
Sprache:eng
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Zusammenfassung:New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.