8-anilinoimidazopyridines and their use as anti-cancer and/or anti-inflammatory agents

The invention relates to imidazopyridines of formula I with anti-cancer and/or anti-inflammatory activity and more specifically to imidazopyridines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperprolife...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Price, Stephen, Heald, Robert, Savy, Pascal Pierre Alexandre
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to imidazopyridines of formula I with anti-cancer and/or anti-inflammatory activity and more specifically to imidazopyridines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.(Formula I)