Antibodies against flagellin and uses thereof

E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter PseudomonasThe present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not lim...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Rachamim, Nurit, Salzman, Andrew L, Murthy, Kanneganti
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter PseudomonasThe present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to, and . The present invention further provides methods of treating inflammatory bowel disease (IBD) and methods of treating enterobacterial infections using anti-flagellin antibodies in humans, other animals and birds.