Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor

Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor

123455678a8b912 Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity, wherein X, X, X, X, X, R, R, R, R, R, R, Z, Zand L are as defined in the description.

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Bibliographische Detailangaben
Hauptverfasser: Lee, Chih-Hung, Bayburt, Erol K, Didomenico, Jr, Stanley, Drizin, Irene, Gomtsyan, Arthur R, Koenig, John R, Perner, Richard J, Schmidt, Jr, Robert G, Turner, Sean C, White, Tammie K, Zheng, Guo Zhu
Format: Patent
Sprache:eng
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Zusammenfassung:123455678a8b912 Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity, wherein X, X, X, X, X, R, R, R, R, R, R, Z, Zand L are as defined in the description.