Screening method for compounds that reduce ER stress

Screening method for compounds that reduce ER stress

The present invention relates to a cell comprising an Endoplasmic Reticulum (ER) stress element operably linked to a reporter element and an exogenous gene encoding a protein that induces ER stress. Methods of screening using the modified cell, constructs used in the modified cell, the candidate age...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Roca, Christophe Francois Aime, Sousa, José Manuel Bernardo, Cerejo, Marta Isabel Heitor, Dos Santos, Alexandra Maria Barros, Rodrigues, Cátia Santana Reverendo, Pinheiro, Ricardo Filipe Antunes, Calado, Patricia Ramalhete Mendes da Silva, Chatterjee, Sukalyan, Vieira, Helena Margarida Moreira de Oliveira
Format: Patent
Sprache:eng
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention relates to a cell comprising an Endoplasmic Reticulum (ER) stress element operably linked to a reporter element and an exogenous gene encoding a protein that induces ER stress. Methods of screening using the modified cell, constructs used in the modified cell, the candidate agents identified by the screen and uses thereof are also part of the invention.