Animal having modification in MGAT2 gene

It is an object to provide a gene-modified non-human animal having inactivated MGAT2 gene and a gene-modified non-human animal cell, which are useful for the search of the function of MGAT2 in vivo. It is another object to provide a method for screening of a compound capable of inhibiting the activi...

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Bibliographische Detailangaben
Hauptverfasser:	Aragane, Katsumi, Ohbuchi, Katsuya, Tamai, Yoshitaka, Harada, Naomoto, Murai, Naomi, Ito, Yoshiki, Kusunoki, Jun, Tokushima, Yukina, Maruyama, Takaharu
Format:	Patent
Sprache:	eng
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Beschreibung
Zusammenfassung:	It is an object to provide a gene-modified non-human animal having inactivated MGAT2 gene and a gene-modified non-human animal cell, which are useful for the search of the function of MGAT2 in vivo. It is another object to provide a method for screening of a compound capable of inhibiting the activity of MGAT2 and a compound capable of inhibiting the activity of MGAT2. It is further another object to provide a method for detecting a disease induced by abnormal lipid metabolism based on the expression level or activity of MGAT2. A method for screening of a compound by using a gene-modified non-human mammal having the artificially inhibited expression of MGAT2 gene and a cell thereof enable to prevent or treat a disease induced by abnormal lipid metabolism. Also a screening of a compound capable of inhibiting or enhancing the function of MGAT2 enables to prevent or treat a disease induced by abnormal lipid metabolism.