Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme

Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme

The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions t...

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Hauptverfasser: Bitner, R. Scott, Browman, Kaitlin E, Brune, Michael E, Fung, Steven, Jacobson, Peer B, Rueter, Lynne E, Strakhova, Marina I, Wang, Jiahong, Rohde, Jeffrey J, Shuai, Qi, Link, James T, Patel, Jyoti R, Dinges, Jurgen, Sorensen, Bryan K, Yong, Hong, Yeh, Vince S, Kurukulasuriya, Ravi
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.