Cannabinoid receptor modulators

1011101110112101122101121011210113 1134 1p1r s2 11 2 34 s2 2 213567 8 1313910 13211 1310 11 35 Compounds of formula (I) are modulators of cannabinoid receptor CB1, useful inter alia for treatment of obesity: Formula (I). Wherein: X is a bond, or a divalent radical selected from -C(R)(R)-*, -C(R)(R)-O-*, -C(R)(R)CH-*, -C(R)(R)CH-O-*, -CHC(R)(R)-*, -CHC(R)(R)-O-*, and -CH-O-C(R)(R)-*, wherein the bond indicated by an asterisk is attached to the pyrazole ring; Z is a carboxyl isostere radical selected from the group specified; Ris hydrogen, (C-C)alkyl or (CC)fluoroalkyl; Ris a radical of formula -(Alk)-(Q)(L)-Qwherein p, r, s, Alk, L, Qand Qare as specified; or Rand Rtaken together with the nitrogen to which they are attached form a cyclic amino ring of 4 to 7 ring atoms which is optionally substituted by a radical of formula -(L)-Qwherein s, L and Qare as defined above, or by an optional substituent selected from hydroxy, methoxy, -NH-, or mono- or di-(CC)alkylamino; R, R, Rand Rare each independently selected from hydrogen -F, -Cl, -Br, -CN, (C-C)alkyl, (CC)fluoroalkyl, cyclopropyl, and -OR; Ris hydrogen, (CC)alkyl, hydroxyl or NH, and Ris hydrogen or (C-C)alkyl; or Rand Rtaken together with the carbon atom to which they are attached form a (C-C)cycloalkyl ring.