Post-translational modifications and clostridial neurotoxins

The present invention discloses modified neurotoxins with altered biological persistence. In one embodiment, the modified neurotoxins are derived from Clostridial botulinum toxins. Such modified neurotoxins may be employed in treating various conditions, including but not limited to muscular disorde...

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Bibliographische Detailangaben
Hauptverfasser: Steward, Lance E, Fernandez-Salas, Ester, Spanoyannis, Athena, Aoki, K. Roger, Lin, Wei-Jen
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention discloses modified neurotoxins with altered biological persistence. In one embodiment, the modified neurotoxins are derived from Clostridial botulinum toxins. Such modified neurotoxins may be employed in treating various conditions, including but not limited to muscular disorders, hyperhidrosis, and pain.