Cycloalkyl derivatives of 3-hydroxy-4-pyridinones

1 2 1 2 1 251 6 36 1 6 1 6 1 6 36 1 6 36 3 1 6 4 1 6 5 1 6 The present invention provides an cycloalkyl derivative of 3-hydroxy-4-pyridinone which is useful for the chelation of metal ions such as iron. Its preparation and use is described. In particular, the invention concerns the removal of iron in chemical and biological systems including chelating agents having the formula I wherein Ris X with the proviso that Ris Y; or Ris T with the proviso that Ris W; or Ris X with the proviso that RRN when taken together form a heterocyclic ring selected from piperidinyl, morpholinyl, pyrrolidinyl or piperazinyl, wherein the group piperidinyl, morpholinyl, pyrrolidinyl or piperazinyl is either unsubstituted or substituted with one to three Cto Calkyl groups. X is C-Ccycloalkyl; Y is selected from the group consisting of Cto Ccycloalkyl; Cto Calkyl, and Cto Calkyl monosubstituted with a C-Ccycloalkyl; T is Cto Calkyl; W is C-Ccycloalkyl; Ris selected from the group consisting of hydrogen and Cto Calkyl; Ris selected from the group consisting of hydrogen and Cto Calkyl; Ris selected from the group consisting of hydrogen and Cto Calkyl; and its pharmaceutically acceptable salt thereof. Pharmaceutical compositions of such compounds are useful in the removal of excess body iron from patients with iron overload diseases.