JAK-2 modulators and methods of use

This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibit...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	Galan, Adam Antoni, Chen, Jeff, Du, Hongwang, Forsyth, Timothy, Huynh, Tai Phat, Johnson, Henry William Beecroft, Kearney, Patrick, Leahy, James W, Lee, Matthew Sangyup, Mann, Grace, Ridgway, Brian Hugh, Takeuchi, Craig Stacy, Zhou, Peiwen
Format:	Patent
Sprache:	eng
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention.