Treating acute renal failure with soluble thrombomodulin variants

The present invention provides a method for preventing and/or treating subjects with acute renal failure caused by a variety of conditions. The method comprises administering to the subject soluble thrombomodulin which does not activate Protein C. In conjunction with standard of care, soluble thromb...

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Bibliographische Detailangaben
Hauptverfasser: Grinnell, Brian William, Jones, Bryan Edward, Molitoris, Bruce A
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention provides a method for preventing and/or treating subjects with acute renal failure caused by a variety of conditions. The method comprises administering to the subject soluble thrombomodulin which does not activate Protein C. In conjunction with standard of care, soluble thrombomodulin that does not activate Protein C will prevent or reduce acute kidney injury and subsequent morbidity and mortality.