Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS)

The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Warren, William L, Drake, III, Donald, Moser, Janice, Singh, Inderpal, Song, Haifeng, Mishkin, Eric, Tew, John G
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.