Mutant phosphoribosylpyrophosphate synthetase and method for producing L-histidine

Mutant phosphoribosylpyrophosphate synthetase and method for producing L-histidine

The present invention relates to a mutant bacterial PRPP synthetase which is resistant to feedback by purine nucleotides, and a method for producing L-histidine using the bacterium of the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by use of the PRPP...

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Hauptverfasser: Klyachko, Elena Vitalievna, Shakulov, Rustem Saidovich, Kozlov, Yuri Ivanovich
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to a mutant bacterial PRPP synthetase which is resistant to feedback by purine nucleotides, and a method for producing L-histidine using the bacterium of the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by use of the PRPP synthetase which is resistant to feedback by purine nucleotides, coded by the mutant prsA gene.