Modification of protein glycosylation in methylotrophic yeast

The present invention relates to methods and genetically engineered methylotrophic yeast strains for producing glycoproteins with mammalian-like glycosylation. The present invention also relates to vectors useful for generating methylotrophic yeast strains capable of producing glycoproteins with mam...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Contreras, Roland, Callewaert, Nico L. M, Vervecken, Wouter, Kaigorodov, Vladimir
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to methods and genetically engineered methylotrophic yeast strains for producing glycoproteins with mammalian-like glycosylation. The present invention also relates to vectors useful for generating methylotrophic yeast strains capable of producing glycoproteins with mammalian-like glycosylation. Glycoproteins produced from the genetically engineered methylotrophic yeast strains are also provided.