Process for the preparation of Tenofovir

The present invention relates to novel Tenofovir disoproxil hemifumarate salt, which is prepared by dealkylation of Phosphonate esters by using mineral acids followed by esterification and crystallization to give crystalline Tenofovir disoproxil. The Tenofovir disoproxil is further converted to fuma...

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Bibliographische Detailangaben
Hauptverfasser:	Vasireddy, Uma Maheswer Rao, Vellanki, Siva Rama Prasad, Balusu, Raja Babu, Bandi, Naga Durga Rao, Jujjavarapu, Pavan Kumar, Ginjupalli, Sambasiva Rao, Pilli, Rama Krishna
Format:	Patent
Sprache:	eng
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The present invention relates to novel Tenofovir disoproxil hemifumarate salt, which is prepared by dealkylation of Phosphonate esters by using mineral acids followed by esterification and crystallization to give crystalline Tenofovir disoproxil. The Tenofovir disoproxil is further converted to fumarate salts with improved yield.