Solution-phase synthesis of leuprolide and its intermediates

A process for producing a nonapeptide leuprolide and an intermediate N-protected oligopetides, wherein at least one peptide bond of the compound is formed by reacting an activated carboxylic acid and an amine component in a continuous flow.

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Bibliographische Detailangaben
Hauptverfasser: Kadzimirsz, Daniel, Jas, Gerhard, Autze, Volker
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:A process for producing a nonapeptide leuprolide and an intermediate N-protected oligopetides, wherein at least one peptide bond of the compound is formed by reacting an activated carboxylic acid and an amine component in a continuous flow.