Histamine H3 receptor agents, preparation and therapeutic uses

The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositio...

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Bibliographische Detailangaben
Hauptverfasser: Beavers, Lisa Selsam, Finley, Don Richard, Gadski, Robert Alan, Hipskind, Philip Arthur, Hornback, William Joseph, Jesudason, Cynthia Darshini, Pickard, Richard Todd, Takakuwa, Takako, Vaught, Grant Mathews
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases. (Formula I).