Locomotive engine multi-fuel control system and method

A method, in certain embodiments, includes controlling a first parameter set (e.g., fuel injection timing, engine speed, etc.) of an engine to reduce specific fuel consumption to account for a plurality of different fuels alone or in combination with one another. The method also may include controlling a second parameter set (e.g., engine duration, engine speed, manifold air pressure, fuel supply temperature, fuel supply pressure, etc.) of the engine to reduce the possibility of exceeding design limits associated with the engine to account for the plurality of different fuels alone or in combination with one another.