Cytokine design

The present invention relates to novel methods for the design of proteins, in particular, cytokines. These methods allow the stabilisation of such cytokines, as well as modification of their selectivity/specificity for their cognate receptors. The invention also relates to various modified proteins...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	Tur, Vicente R, Van der Sloot, Albert Martinus, Mullally, Margaret M, Cool, Robbert H, Szegezdi, Eva E, Samali, Afshin, Fernandez-Ballester, Gregorio, Serrano, Luis, Quax, Wilhelmus J
Format:	Patent
Sprache:	eng
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The present invention relates to novel methods for the design of proteins, in particular, cytokines. These methods allow the stabilisation of such cytokines, as well as modification of their selectivity/specificity for their cognate receptors. The invention also relates to various modified proteins that have been designed by the methods of the invention.