Process for the preparation of a composition of genetically modified hematopoietic progenitor cells

Process for the preparation of a composition of genetically modified hematopoietic progenitor cells

Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of using them to provide prolonged engraftment of modified hematopoietic cells in human subjects. The inv...

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Bibliographische Detailangaben
Hauptverfasser: Symonds, Geoffrey P, Amado, Rafael, Sun, Lun-Quan, Macpherson, Janet, Fanning, Greg, Gerlach, Wayne
Format: Patent
Sprache:eng
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Zusammenfassung:Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of using them to provide prolonged engraftment of modified hematopoietic cells in human subjects. The invention particularly relates to ex vivo gene therapy of HP cells for treatment or prevention of HIV infection.