Classes of compounds that interact with GPCRs

The present invention relates to a method of identifying a candidate therapeutic agent. The method comprises contacting a G-Protein Coupled Receptor (GPCR) with a compound of General Formula (I), or a pharmaceutically acceptable salt thereof determining whether the compound inhibits or effects signa...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Meutermans, Wim, Le Thanh, Glang, Abbenante, Giovanni, Tometzki, Gerald, Halliday, Judy, Zuegg, Johannes
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to a method of identifying a candidate therapeutic agent. The method comprises contacting a G-Protein Coupled Receptor (GPCR) with a compound of General Formula (I), or a pharmaceutically acceptable salt thereof determining whether the compound inhibits or effects signal transduction activity of the GPCR, wherein a compound that inhibits or effects the activity of the GPCR is a candidate therapeutic agent.