Mutant GTP cyclohydrolase II enzymes

The present invention relates to modified GTP cyclohydrolase II enzymes that display increased specific activity, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The invention provides a method f...

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Bibliographische Detailangaben
Hauptverfasser: Ebert, Sybille, Hohnmann, Hans-Peter, Lehmann, Martin, Mouncey, Nigel John, Wyss, Markus
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to modified GTP cyclohydrolase II enzymes that display increased specific activity, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The invention provides a method for producing the modified enzyme and a method for producing riboflavin, a riboflavin precursor, FMN, FAD, or a derivative thereof.