Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

The present invention discloses novel compounds of Formula (I): having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I), as well as methods of using the...

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Hauptverfasser: Aicher, Thomas Daniel, Anzeveno, Peter Biagio, Li, Renhua, Krasutsky, Alexei Pavlovych, Mabry, Thomas Edward, Saeed, Ashraf, Snyder, Nancy June, Tian, Hongqi, Wallace, Owen Brendan, Winneroski, Leonard Larry, Xu, Yanping
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention discloses novel compounds of Formula (I): having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I), as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11β-HSD type 1 activity.