Accessible content reputation lookup

Implementations of accessible content reputation lookup are described. In one implementation, before a user activates a link in a document, such as a hyperlink on a webpage, the user can designate the link. For example, the user can float a cursor over the link or interact with an icon placed proximate to the link. By designating the link, the user can request reputation information associated with the link, including information as to whether or not content associated with the link, an application used to access the content, and/or source(s) on which the content resides, are known to be dangerous or risky. If the reputation information indicates that the link is safe to activate, the user can activate the link and access the content. Alternately, if the reputation information indicates that the link is unsafe to access, the user can choose to forego activation of the link.