Protein formulations for use at elevated temperatures

Liquid formulations of bone morphogenetic proteins are provided for prolonged use at elevated temperatures. More specifically, the invention relates to liquid formulations comprising rhGDF-5, trehalose, and one or more biocompatible excipients that provide stability to the protein for at least 30 da...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Garigapati, Venkata, Su, Dongling, Lopez, Julius
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Liquid formulations of bone morphogenetic proteins are provided for prolonged use at elevated temperatures. More specifically, the invention relates to liquid formulations comprising rhGDF-5, trehalose, and one or more biocompatible excipients that provide stability to the protein for at least 30 days at temperatures up to body temperature.