Method of measuring the biological activity of an urotensin II receptor

Method of measuring the biological activity of an urotensin II receptor

Administration of U-II to rats caused an increase in the redness or the skin temperature of the ear of the rats. The increase was inhibited by compounds that decease the biological activity of the U-II/UT receptor. Thus, the present invention provides methods of measuring the biological activity of...

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Hauptverfasser: Schulingkamp, Robert, Qi, Jianshen, Colburn, Raymond, Stone, Dennis, Van Besien, Christopher, Minor, Lisa, Andrade-Gordon, Patricia, Damiano, Bruce
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Sprache:eng
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creator Schulingkamp, Robert
Qi, Jianshen
Colburn, Raymond
Stone, Dennis
Van Besien, Christopher
Minor, Lisa
Andrade-Gordon, Patricia
Damiano, Bruce
description Administration of U-II to rats caused an increase in the redness or the skin temperature of the ear of the rats. The increase was inhibited by compounds that decease the biological activity of the U-II/UT receptor. Thus, the present invention provides methods of measuring the biological activity of an U-II receptor by monitoring the redness or the skin temperature of the ear of an animal, and the use of the methods to test compounds for their abilities to increase or decrease the biological activity of an U-II receptor.
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title Method of measuring the biological activity of an urotensin II receptor
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