Method of measuring the biological activity of an urotensin II receptor

Administration of U-II to rats caused an increase in the redness or the skin temperature of the ear of the rats. The increase was inhibited by compounds that decease the biological activity of the U-II/UT receptor. Thus, the present invention provides methods of measuring the biological activity of...

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Bibliographische Detailangaben
Hauptverfasser:	Schulingkamp, Robert, Qi, Jianshen, Colburn, Raymond, Stone, Dennis, Van Besien, Christopher, Minor, Lisa, Andrade-Gordon, Patricia, Damiano, Bruce
Format:	Patent
Sprache:	eng
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	Administration of U-II to rats caused an increase in the redness or the skin temperature of the ear of the rats. The increase was inhibited by compounds that decease the biological activity of the U-II/UT receptor. Thus, the present invention provides methods of measuring the biological activity of an U-II receptor by monitoring the redness or the skin temperature of the ear of an animal, and the use of the methods to test compounds for their abilities to increase or decrease the biological activity of an U-II receptor.