Humanized anti-amyloid beta antibodies

Humanized anti-Aβ antibodies derived from a murine antibody directed to a N-terminal epitope of Aβ are described. The humanized antibodies have reduced or no human T cell epitopes and bind Aβ with an affinity similar to that of the murine antibody.

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Bibliographische Detailangaben
Hauptverfasser: Shafer, Lisa Lynn, Carr, Francis Joseph, Gregson, James Peter, Bembridge, Dawn Ann, Jones, Tim
Format: Patent
Sprache:eng
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Zusammenfassung:Humanized anti-Aβ antibodies derived from a murine antibody directed to a N-terminal epitope of Aβ are described. The humanized antibodies have reduced or no human T cell epitopes and bind Aβ with an affinity similar to that of the murine antibody.