Pyrrolotriazine compounds as kinase inhibitors

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are als...

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Bibliographische Detailangaben
Hauptverfasser: Fink, Brian E, Gavai, Ashvinikumar V, Vite, Gregory D, Chen, Ping, Mastalerz, Harold, Norris, Derek J, Tokarski, John S, Zhao, Yufen, Han, Wen-Ching
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.