Optimizing expression of active Botulinum Toxin type E

Optimizing expression of active Botulinum Toxin type E

Nucleic acid molecules that comprise modified open reading frames providing increased expression of the encoded active BoNT/E in a heterologous cell, expression constructs and cells comprising such nucleic acid molecules and methods useful for expressing the encoding active BoNT/E from such nucleic...

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Bibliographische Detailangaben
Hauptverfasser: Steward, Lance E, Gilmore, Marcella A, Fernandez-Salas, Ester G, Li, Shengwen, Miller, Ronald G, Aoki, Kei Roger
Format: Patent
Sprache:eng
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Zusammenfassung:Nucleic acid molecules that comprise modified open reading frames providing increased expression of the encoded active BoNT/E in a heterologous cell, expression constructs and cells comprising such nucleic acid molecules and methods useful for expressing the encoding active BoNT/E from such nucleic acid molecules, expression constructs and cells.