Universal optical imaging and processing system

The disclosure is directed to a test media reader module including a housing, a membrane, and an optical imager. The housing is configured to receive a test media adapter and has a barrier wall configured to separate the test media adapter from an interior of the housing. The barrier wall includes a window having an interior side and an exterior side. The membrane is transparent to a wavelength useful for imaging test media in the test media adapter. The membrane has a reactive region and overlies at least a portion of the exterior side of the window. The optical imager is located interior to the housing and is configured to image the test media located on the exterior side of the window along an optical path extending through the window and the membrane.