Substituted pyrimidinones

1245 Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R, R, R, and Rare defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions contain...

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Bibliographische Detailangaben
1. Verfasser: Durley, Richard C
Format: Patent
Sprache:eng
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Zusammenfassung:1245 Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R, R, R, and Rare defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.