Preparing method of methoxypolyethyleneglycol and its derivatives

The present invention relates to a preparing method of methoxypolyethyleneglycol (mPEG) with high purity and derivatives thereof. More precisely, the method of the present invention to prepare high purity mPEG with at least 99% of purity, up to 1.05 of molecular weight distribution and 350˜100,000 o...

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Bibliographische Detailangaben
Hauptverfasser: Park, Pyeong-Uk, Kim, Seong-Neon, Lee, Chong-Gu, Lee, Ju-Sung
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to a preparing method of methoxypolyethyleneglycol (mPEG) with high purity and derivatives thereof. More precisely, the method of the present invention to prepare high purity mPEG with at least 99% of purity, up to 1.05 of molecular weight distribution and 350˜100,000 of molecular weight includes the process of reacting commercial mPEG having low purity to give highly purified intermediates, mPEG-acetic acid of formula 1 and mPEG-phthalate of formula 2.