Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity

This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the su...

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Bibliographische Detailangaben
Hauptverfasser:	Allen, Jennifer R, Biswas, Kaustav, Burli, Roland, Dao, Jennifer, Frohn, Michael J, Golden, Jennifer E, Hungate, Randall W, Kurzeja, Robert, Mercede, Stephanie J, Muller, Kristine M, Neira, Susana C, Peterkin, Tanya A. N, Tegley, Christopher M, Yu, Violeta
Format:	Patent
Sprache:	eng
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.