Beta-carbolines useful for treating inflammatory disease

Beta-carbolines useful for treating inflammatory disease

12 3 This invention provides beta-carboline compounds of formula I: wherein Ring A is a substituted pyridinyl, pyrimidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyranyl, tetrahydrofuranyl, cyclohexyl, cyclopentyl or thiomorpholinyl ring and R, Rand Rare as described in the specificat...

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Bibliographische Detailangaben
Hauptverfasser: Hepperle, Michael E, Liu, Julie Fields, Soucy, Francois, Ye, Yingchun, Murray, Robert S, Prakash, Raman, Little, Jeremy D, Castro, Alfredo, Mazdiyasni, Hormoz, Fleming, Paul E, Reynolds, Dominic
Format: Patent
Sprache:eng
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Zusammenfassung:12 3 This invention provides beta-carboline compounds of formula I: wherein Ring A is a substituted pyridinyl, pyrimidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyranyl, tetrahydrofuranyl, cyclohexyl, cyclopentyl or thiomorpholinyl ring and R, Rand Rare as described in the specification. The compounds are IKK-2 inhibitors that are useful for treating IKK-2-mediated diseases such as inflammatory diseases and cancer.