Heterobicyclic metalloprotease inhibitors

The present invention relates generally to azabicyclic containing pharmaceutical agents, and in particular, to azabicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azabicyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, which exhibit...

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Bibliographische Detailangaben
Hauptverfasser:	Gege, Christian, Schneider, Matthias, Chevrier, Carine, Deng, Hongbo, Sucholeiki, Irving, Gallagher, Jr, Brian M, Bosies, Michael, Steeneck, Christoph, Wu, Xinyuan, Hochgürtel, Matthias, Nolte, Bert, Taveras, Arthur
Format:	Patent
Sprache:	eng
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Beschreibung
Zusammenfassung:	The present invention relates generally to azabicyclic containing pharmaceutical agents, and in particular, to azabicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azabicyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, which exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.